Inhibition of Endothelial Cell Differentiation and Proinflammatory Cytokine Production During Angiogenesis by Allyl Isothiocyanate and Phenyl Isothiocyanate
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چکیده
منابع مشابه
Allyl isothiocyanate affects the cell cycle of Arabidopsis thaliana
Isothiocyanates (ITCs) are degradation products of glucosinolates present in members of the Brassicaceae family acting as herbivore repellents and antimicrobial compounds. Recent results indicate that allyl ITC (AITC) has a role in defense responses such as glutathione depletion, ROS generation and stomatal closure. In this study we show that exposure to non-lethal concentrations of AITC causes...
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Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, is widely and often frequently consumed by humans. Besides antimicrobial activity against a wide spectrum of pathogens, it showed anticancer activity in both cultured cancer cells and animal models, although the underlining mechanisms remain largely undefined. Bioavailability of AITC is extremely high, as nearly 90...
متن کاملInhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate.
The growing interest in the use of natural herbal products and dietary supplements to treat and prevent diseases raises the question of medicinal drug safety. Allyl isothiocyanate, a hydrolysis product of a glucosinolate, sinigrin, has multiple beneficial properties, and based on this fact, allyl isothiocyanate-containing dietary supplements have been developed. To date, no studies of the effec...
متن کاملNear-silence of isothiocyanate carbon in (13)C NMR spectra: a case study of allyl isothiocyanate.
(1)H and (13)C NMR spectra of allyl isothiocyanate (AITC) were measured, and the exchange dynamics were studied to explain the near-silence of the ITC carbon in (13)C NMR spectra. The dihedral angles α = ∠(C1-C2-C3-N4) and β = ∠(C2-C3-N4-C5) describe the conformational dynamics (conformation change), and the bond angles γ = ∠(C3-N4-C5) and ε = ∠(N4-C5-S6) dominate the molecular dynamics (confor...
متن کاملNear-Silence of Isothiocyanate Carbon in C NMR Spectra: A Case Study of Allyl Isothiocyanate
H and C NMR spectra of allyl isothiocyanate (AITC) were measured, and the exchange dynamics were studied to explain the near-silence of the ITC carbon in C NMR spectra. The dihedral angles α = ∠(C1−C2−C3−N4) and β = ∠(C2−C3−N4−C5) describe the conformational dynamics (conformation change), and the bond angles γ = ∠(C3−N4−C5) and ε = ∠(N4−C5−S6) dominate the molecular dynamics (conformer flexibi...
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ژورنال
عنوان ژورنال: Integrative Cancer Therapies
سال: 2007
ISSN: 1534-7354,1552-695X
DOI: 10.1177/1534735407309084